Package: dfmeta 1.0.0
dfmeta: Meta-Analysis of Phase I Dose-Finding Early Clinical Trials
Meta-analysis approaches for Phase I dose finding early phases clinical trials in order to better suit requirements in terms of maximum tolerated dose (MTD) and maximal dose regimen (MDR). This package has currently three different approaches: (a) an approach proposed by Zohar et al, 2011, <doi:10.1002/sim.4121> (denoted as ZKO), (b) the Variance Weighted pooling analysis (called VarWT) and (c) the Random Effects Model Based (REMB) algorithm, where user can input his/her own model based approach or use the existing random effect logistic regression model (named as glimem) through the 'dfmeta' package.
Authors:
dfmeta_1.0.0.tar.gz
dfmeta_1.0.0.zip(r-4.5)dfmeta_1.0.0.zip(r-4.4)dfmeta_1.0.0.zip(r-4.3)
dfmeta_1.0.0.tgz(r-4.5-any)dfmeta_1.0.0.tgz(r-4.4-any)dfmeta_1.0.0.tgz(r-4.3-any)
dfmeta_1.0.0.tar.gz(r-4.5-noble)dfmeta_1.0.0.tar.gz(r-4.4-noble)
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dfmeta.pdf |dfmeta.html✨
dfmeta/json (API)
| # Install 'dfmeta' in R: |
| install.packages('dfmeta', repos = c('https://artemis-toumazi.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/artemis-toumazi/dfmeta/issues
- Toxdata - A toxicity database.
Last updated 7 years agofrom:2e992a7d1b. Checks:6 OK, 3 NOTE. Indexed: yes.
| Target | Result | Latest binary |
|---|---|---|
| Doc / Vignettes | OK | Apr 02 2025 |
| R-4.5-win | NOTE | Apr 02 2025 |
| R-4.5-mac | NOTE | Apr 02 2025 |
| R-4.5-linux | NOTE | Apr 02 2025 |
| R-4.4-win | OK | Apr 02 2025 |
| R-4.4-mac | OK | Apr 02 2025 |
| R-4.4-linux | OK | Apr 02 2025 |
| R-4.3-win | OK | Apr 02 2025 |
| R-4.3-mac | OK | Apr 02 2025 |
Exports:doseRecordsfindFirstLastglimemMA_estimatesplotshowVarWTZKO
Dependencies:bootclicolorspacedata.tablefansifarverggplot2gluegtableisobandlabelinglatticelifecyclelme4magrittrMASSMatrixmgcvminqamunsellnlmenloptrpillarpkgconfigplyrR6rbibutilsRColorBrewerRcppRcppEigenRdpackreformulasrlangscalestibbleutf8vctrsviridisLitewithr
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| Meta-Analysis of Phase I Dose-Finding Early Phases Clinical Trials. | dfmeta-package dfmeta |
| Random Effect Analysis | doseRecords |
| The first or the last occurence of a unique value. | findFirstLast |
| The logistic regression mixed effect model. | glimem |
| Executing the random effect model-based algorithm (REMB). | MA_estimates |
| The graphical representation of dose-toxicity curve. | plot,ZKO,missing-method |
| An S4 class to represent the results using the random effect model-based (REMB) algorithm. | REMB-class |
| S4 Methods for Function 'show' | show,REMB-method show,ZKO-method show-methods |
| A toxicity database. | Toxdata |
| The variance weighted (VarWT) pooling approach. | VarWT |
| Meta-analysis approach based on Zohar et al, 2011. | ZKO |
| An S4 class to represent the results using the ZKO algorithm. | ZKO-class |
